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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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DOI

10.1016/0277-9390(93)90031-j

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1435-5922

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Lowdose aspirininduced gastrointestinal diseases

Authors: Akiko Shiotani Tomoari Kamada Ken Haruma
Publish Date: 2008/08/17
Volume: 43, Issue: 8, Pages: 581-588
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Abstract

Metaanalyses of randomized placebocontrolled trials of lowdose aspirin indicate that aspirin approximately doubles the risk of major GI bleeding compared with placebo The risk in Japanese may possibly be higher compared to Western populations although the evidence is still lacking and prospective studies are required Prior GI events older age and use of other injurious medicines such as NSAIDs anticoagulants and corticosteroids seem to be factors associated with an increased risk for upper GI bleeding among aspirin users Prospective studies are needed to identify specific risk factors for upper GI bleeding in Japanese patients taking lowdose aspirin There are many potential gastroprotective drugs available in Japan and studies are needed to assess the relative effectiveness of various strategies including PPI use for the prevention of aspirinrelated upper GI ulcer complications and whether any of these other agents also provide protection against small bowel or colonic damage Aspirininduced enteropathy is now increasingly being recognized and is presumably not uncommon and the availability of new imaging techniques for the small intestine and noninvasive tests such as fecal calprotectin should allow rapid progress in this important area

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