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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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DOI

10.1002/ccd.1810050306

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1435-5922

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Prognostic significance of the modified Glasgow pr

Authors: Kotaro Hirashima Masayuki Watanabe Hironobu Shigaki Yu Imamura Satoshi Ida Masaaki Iwatsuki Takatsugu Ishimoto Shiro Iwagami Yoshifumi Baba Hideo Baba
Publish Date: 2013/07/03
Volume: 49, Issue: 6, Pages: 1040-1046
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Abstract

The Glasgow prognostic score GPS is a preoperatively determined inflammationbased score Reports suggest a significant correlation between the GPS and prognosis in several cancer types We aimed to clarify the prognostic significance of the modified GPS mGPS in patients undergoing gastrectomy for gastric cancerTwo hundred and ninetyfour patients with gastric cancer 195 aged  75 years group NE and 99 aged  75 years group E who underwent gastrectomy from March 2005 to March 2011 were enrolled Patients with an elevated Creactive protein level  05 mg/dL and hypoalbuminemia  38 g/dL were assigned a mGPS of 2 those with either 1 abnormality were assigned a mGPS of 1 and those with neither abnormality were assigned a mGPS of 0 Cox proportional hazard models and Kaplan–Meier analysis were used to evaluate the usefulness of mGPS as a prognostic indicatorIn the NE group the prognosis of the 3 groups stratified by mGPS did not differ significantly In multivariate Cox regression analysis the type of gastrectomy peritoneal metastasis and stage were independently associated with poor prognosis However group E patients with a mGPS of 2 had significantly poorer prognosis than those with a mGPS of 0 or 1 In this age group stage and mGPS were independently associated with poor prognosis

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