Journal Title
Title of Journal: J Mater Sci Mater Med
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Abbravation: Journal of Materials Science: Materials in Medicine
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Authors: Karsten Hemmrich Jochen Salber Melanie Meersch Ute Wiesemann Thomas Gries Norbert Pallua Doris Klee
Publish Date: 2007/06/28
Volume: 19, Issue: 1, Pages: 257-267
Abstract
Biodegradable polyesters are established biomaterials in medicine due to their chemical characteristics and options for material processing A main problem however is the release of acid degradation products during biodegradation with severe local pHdrops and inflammatory reactions Polyesteramides in contrast show a less prominent pHdrop during degradation In this study we developed a simple reproducible synthesis of the polyester amide PEA type C starting from εcaprolactame 14butanediol and adipic acid in a onebatch twostep reaction and conducted the manufacturing of PEAderived 3D textile scaffolds applicable for tissue engineering purposes The thermal and mechanical properties of PEAtype C were analysed and the structural conformity of different batches was confirmed by NMR spectroscopy and size exclusion chromatography The polymer was formed into nonwovens by textile manufacturing Cytotoxicity tests and Xray photoelectron spectroscopy XPS were used to analyze the effect of scaffold extraction before cell seeding The manufactured carriers were seeded with human preadipocytes and examined for cellular proliferation and differentiation The production of PEA type C successfully occurred via simultaneous ringopening polymerization of εcaprolactame and polycondensation with 14butanediol and adipic acid at 250 °C under highvacuum Soxhlet extraction allowed optimal cleaning of nonwoven scaffolds Extracted PEAderived matrices were capable of allowing good adherence proliferation and differentiation of preadipocytes These results are encouraging and guidance towards an optimally prepared nonwoven carrier applicable for clinical useThis research work is part of a project funded by the “HOLSTEStiftung” of the RWTH Aachen University Additionally the Federal Ministry of Economics and Labour BMWA = Bundesministerium für Wirtschaft und Arbeit and its partner organisation the German Federation of Industrial Research Associations “Otto von Guericke” Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” eV are gratefully thanked for financial support of the research project AiFNo 107 ZN/1 The authors are also grateful to the DECHEMA Society for Chemical Engineering and Biotechnology for cooperation
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Other Papers In This Journal:
- Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves
- Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone
- Injectability of brushite-forming Mg-substituted and Sr-substituted α-TCP bone cements
- Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair
- Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds
- The impact of the RGD peptide on osteoblast adhesion and spreading on zinc-substituted hydroxyapatite surface
- Nano-hydroxyapatite/poly( l -lactic acid) composite synthesized by a modified in situ precipitation: preparation and properties
- Poly ( d , l -lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation
- Bone-like apatite coating on Mg-PSZ/Al 2 O 3 composites using bioactive systems
- Using chondroitin sulfate to improve the viability and biosynthesis of chondrocytes encapsulated in interpenetrating network (IPN) hydrogels of agarose and poly(ethylene glycol) diacrylate
- The preparation, cytocompatibility, and in vitro biodegradation study of pure β-TCP on magnesium
- Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics
- Preparation and characterization of biphasic calcium phosphate ceramics of desired composition
- Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent
- Artifact level produced by different femoral head prostheses in CT imaging: diamond coated silicon nitride as total hip replacement material
- Peptide immobilization on polyethylene terephthalate surfaces to study specific endothelial cell adhesion, spreading and migration
- In vitro and in vivo evaluation of the effects of demineralized bone matrix or calcium sulfate addition to polycaprolactone–bioglass composites
- Osteoblast attachment to hydroxyapatite micro-tube scaffolds
- Hydrolysis of monetite/chitosan composites in α-MEM and SBF solutions
- Apatite-forming PEEK with TiO 2 surface layer coating
- Surface silver-doping of biocompatible glass to induce antibacterial properties. Part I: massive glass
- Long-term in vivo experimental investigations on magnesium doped hydroxyapatite bone substitutes
- Comparison of two polymeric carrier formulations for controlled release of hydrophilic and hydrophobic drugs
- Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms
- Monitoring cellular behaviour using Raman spectroscopy for tissue engineering and regenerative medicine applications
- Cellulose film regenerated from Styela clava tunics have biodegradability, toxicity and biocompatibility in the skin of SD rats
- Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol
- Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel
- Self-dissolving micropile array tips for percutaneous administration of insulin
- Dental casting alloys behaviour during power toothbrushing with toothpastes with various abrasivities. Part I: wear behavior
- Fabrication, chemical composition change and phase evolution of biomorphic hydroxyapatite
- Methotrexate-grafted-oligochitosan micelles as drug carriers: synthesis and biological evaluations
- Influence of light polymerization modes on degree of conversion and crosslink density of dental composites
- Equilibrium and non-equilibrium charge-dependent quantification of endothelial cell hydrogel scaffolds
- Microstructure and wear properties of LENS ® deposited medical grade CoCrMo
- Comparison of tensile and knot security properties of surgical sutures
- Enhanced wear and fatigue properties of Ti–6Al–4V alloy modified by plasma carburizing/CrN coating
- Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery
- Quantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix
- Fabrication of bioactive hydroxyapatite/bis-GMA based composite via three dimensional printing
- Biomechanical characterisation of a degradable magnesium-based (MgCa0.8) screw
- Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
- Surface characterization and biological properties of regular dentin, demineralized dentin, and deproteinized dentin
- Fabrication and mechanical testing of porous calcium phosphate bioceramic granules
- Novel carboxymethyl chitosan-graphene oxide hybrid particles for drug delivery
- Regulatory biocompatibility requirements for biomaterials used in regenerative medicine
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