Authors: Adam Bohr Feng Wan Jakob Kristensen Mark Dyas Eleanor Stride Stefania Baldursdottír Mohan Edirisinghe Mingshi Yang
Publish Date: 2015/01/29
Volume: 26, Issue: 2, Pages: 61-
Abstract
Microparticles of Celecoxib dispersed in a matrix of polylacticcoglycolic acid PLGA were prepared by electrospraying using different solvent mixtures to investigate the influence upon particle formation and the resulting particle characteristics Mixtures consisting of a good solvent acetone and an antisolvent methanol for PLGA were studied in different ratios Properties of the spraying solutions were examined and the resulting microparticles were characterized with regard to size morphology porosity solid state form surface chemistry and drug release Particle formation was strongly influenced by the polymer molecular conformation during droplet formation and by the antisolvent concentration during droplet drying A strong correlation was found between particle morphology and the solubility of the polymer in the solvent mixtures The lack of chain entanglements in droplets containing antisolvent resulted in compact polymer conformation and grainlike particle morphology Further the early precipitation of polymer and low chain interaction with increasing content of antisolvent resulted in surface enrichment of drug from 10 and 20 up to 41 and 57 respectively also demonstrated by the increasingly higher drug release rates The results demonstrate the importance of solvent composition in particle preparation and indicate potential for exploiting this dependence to improve pharmaceutical particle design and performance
Keywords: