Authors: Yunfeng Shi Zhipeng Xiong Xuefei Lu Xin Yan Xiang Cai Wei Xue
Publish Date: 2016/10/04
Volume: 27, Issue: 11, Pages: 169-
Abstract
We describe an electrostatic droplet generation method to prepare a novel carboxymethyl chitosan−graphene oxide hybrid particles for delivery purpose Under an adjustable electrostatic field graphene oxide and carboxymethyl chitosan mixed solution was sprayed as uniform microdroplets which were solidified as particles in CaCl2 solution Such hybrid particles are wished to have excellent stability in saline solution and better delivery properties than pristine carboxymethyl chitosan particles The effects of microdroplets generation conditions on particles formation were systematically investigated At conditions of 40 mg/ml of carboxymethyl chitosan 2 mg/ml of graphene oxide 3 ml/h of feed speed electrostatic field parameters was 9 kV and 20 cm uniformly sized carboxymethyl chitosan–graphene oxide particles in the diameter range of 250–300 μm was successfully prepared In NaCl saline these particles could maintain stable for at least a week while pristine carboxymethyl chitosan particles quickly collapsed within an hour The results of loading experiments showed that carboxymethyl chitosan–graphene oxide particles could effectively adsorb gatifloxacin ofloxacin bovine serum albumin lysozyme doxorubicin hydrochloride And gatifloxacin was chosen as a model drug to study the exact effect of graphene oxide content on the loading and release properties In 402 group the highest loading capacity of 045 ± 019 mg/mg was achieved and also a good sustained release was available Above all we believed that carboxymethyl chitosan–graphene oxide particles as a versatile carrier has great potential in Medicine and Pharmacy
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