Authors: Jinzhou Zhu Huizhu Liu Haipo Cui Zhirong Tang Chengli Song Ruiyan Zhang
Publish Date: 2017/02/14
Volume: 28, Issue: 3, Pages: 54-
Abstract
Late stent thrombosis LST following drugeluting stent DES implantation in patients with coronary artery disease CAD is often associated with delayed vascular healing resulting from vascular inflammation and hypersensitivity to durable polymers and drugs Therefore DES design materials and coatings have been technologically revolutionized Herein we designed a novel abluminal groovefilled biodegradable polymer sirolimuseluting stent AGFBPSES with a sirolimus content of only about onethird of traditional DES The mechanical performances of AGFBPSES during compression and expansion were investigated The pharmacokinetic PK profile of sirolimus was studied in the swine model The in vivo efficacy of AGFBPSES was compared with that of Xience PRIME® stent The results showed that AGFBPSES exhibited mechanical properties similar to traditional DES including the rebound ratio of radial contraction/direction rebound ratio of axial contraction/direction and inhomogeneity of compression/expansion Despite utilizing a reduced dose of sirolimus AGFBPSES delivered sirolimus to the coronary artery in a controlled and efficient manner The stent maintained a safe and effective local drug concentration without local or systemic risks In the swine model histopathological indicators predicted safety and biocompatibility of AGFBPSES In conclusion AGFBPSES maintained similar mechanical properties as other stents while reducing the drugloading capacity and showed a favorable safety and efficacy profile of the targeted DES
Keywords: