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Title of Journal: J Mater Sci Mater Med

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Abbravation: Journal of Materials Science: Materials in Medicine

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Springer US

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DOI

10.1016/0305-4179(93)90122-O

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1573-4838

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Longterm in vivo experimental investigations on m

Authors: M Sartori G Giavaresi M Tschon L Martini L Dolcini M Fiorini D Pressato M Fini
Publish Date: 2014/02/20
Volume: 25, Issue: 6, Pages: 1495-1504
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Abstract

Despite several efforts to find suitable alternatives to autologous bone no bone substitute currently available provides the same characteristics and properties Nevertheless among the wide range of materials proposed as bone substitutes calcium phosphate materials represent the most promising category and the present study is aimed at improving the knowledge on nonstoichiometric magnesiumdoped hydroxyapatite substitutes MgHA tested in two different formulations MgHA Putty and MgHA Granules These bone substitutes were implanted bilaterally into iliac crest bone defects in healthy sheep and comparative histological histomorphometric microhardness and ultrastructural assessments were performed 9 12 18 and 24 months after surgery to elucidate bone tissue apposition mineralization and material degradation in vivo The results confirmed that the biomimetic bone substitutes provide a histocompatible and osteoconductive structural support during the bone formation process and give essential information about the in vivo resorption process and biological behavior of biomimetic bone substitutesThe authors are grateful to Dr M C Maltarello for his excellent assistance in EDS investigation and also to Mr Keith Smith for his assistance in language supervision This paper was partially supported by Rizzoli Orthopaedic Institute “5 PER MILLE ProjectYear 2010”This study was supported by a grant from FinCeramica Faenza SpA Faenza RA Italy for providing biomaterial costs of animals animal housing and analyses Dolcini L and Pressato D are employees of this company and declare the existence of a potential conflict of interest The other authors declare no conflict of interest with the materials used in the present evaluation


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