Authors: E Verné M Miola C Vitale Brovarone M Cannas S Gatti G Fucale G Maina A Massé S Di Nunzio
Publish Date: 2008/11/06
Volume: 20, Issue: 3, Pages: 733-740
Abstract
A glass belonging to the system SiO2–Al2O3–CaO–Na2O has been subjected to a patented ionexchange treatment to induce surface antibacterial activity by doping with silver ions Doped samples have been characterized by means of XRay diffraction XRD scanning electron microscopy SEM observation energy dispersion spectrometry EDS analysis in vitro bioactivity test Ag+ leaching test by graphite furnace atomic absorption spectroscopy GFAAS analyses cytotoxicity tests by fibroblasts adhesion and proliferation adsorption of IgA and IgG on to the material to evaluate its inflammatory property and antibacterial tests cultures with Staphylococcus aureus and Escherichia coli In vitro tests results demonstrated that the modified glass maintains the same biocompatibility of the untreated one and moreover it acquires an antimicrobial action against tested bacteria This method can be selected to realize glass or glassceramic bone substitutes as well as coatings on bioinert devices providing safety against bacterial colonization thus reducing the risks of infections nearby the implant site The present work is the carrying on of a previous research activity concerning the application of an ionexchange treatment on glasses belonging to the ternary system SiO2–CaO–Na2O On the basis of previous results the glass composition was refined and the ionexchange process was adapted to it in order to tune the final material properties The addition of Al2O3 to the original glass system and the optimization of the ionexchange conditions allowed a better control of the treatment leading to an antibacterial material without affecting both bioactivity and biocompatibility
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