Journal Title
Title of Journal: J Mater Sci Mater Med
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Abbravation: Journal of Materials Science: Materials in Medicine
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Authors: Jie Ren Peng Zhao Tianbin Ren Shuying Gu Kefeng Pan
Publish Date: 2007/08/15
Volume: 19, Issue: 3, Pages: 1075-1082
Abstract
Biodegradable polymer/bioceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping However conventional methods for fabricating polymer/bioceramic composite scaffolds often use organic solvents eg the solvent casting and particulate leaching SC/PL method which might be harmful to cells or tissues In this study Poly dllactide/nanohydroxyapatite PDLLA/NHA composites were prepared by insitu polymerization and highly porous scaffolds were fabricated using a novel method supercritical CO2/saltleaching method SC CO2/SL The materials and scaffolds were investigated by scanning electronic microscopy SEM transmission electronic microscopy TEM and gel permeation chromatography GPC GPC showed that the molecular weight of composites decreased with increase of NHA content However the water absorption and compressive strength increased dramatically The SEM micrographs showed that the scaffolds with pore size about 250 μm were obtained by controlling parameters of SC CO2/SL The biocompatibility of PDLLA/NHA porous scaffolds were evaluated in vitro and in vivo The evaluation on the cytotoxicity were carried out by cell relative growth rate RGR method and cell direct contact method The cytotoxicity of these scaffolds was in grade I according to ISO 109931 There was no toxicosis and death cases observed in acute systemic toxicity test And histological observation of the tissue response 1 and 9 weeks after the implantation showed that there are still some slight inflammation responsesThe project is sponsored by the key basic research foundation for development of science and technology of Shanghai PR of China Number 05DJ14006 the research foundation for nano science and technology special project of Shanghai Number 0452nm088 Contract grant sponsor Key Basic Research Foundation for Development of Science and Technology of Shanghai PR of China contract grant number 05DJ14006 The research foundation for nano science and technology special project of Shanghai PR of China contract grant number 0452nm088
Keywords:
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Other Papers In This Journal:
- Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves
- Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone
- Injectability of brushite-forming Mg-substituted and Sr-substituted α-TCP bone cements
- Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair
- Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds
- The impact of the RGD peptide on osteoblast adhesion and spreading on zinc-substituted hydroxyapatite surface
- Nano-hydroxyapatite/poly( l -lactic acid) composite synthesized by a modified in situ precipitation: preparation and properties
- Bone-like apatite coating on Mg-PSZ/Al 2 O 3 composites using bioactive systems
- Using chondroitin sulfate to improve the viability and biosynthesis of chondrocytes encapsulated in interpenetrating network (IPN) hydrogels of agarose and poly(ethylene glycol) diacrylate
- The preparation, cytocompatibility, and in vitro biodegradation study of pure β-TCP on magnesium
- Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics
- Preparation and characterization of biphasic calcium phosphate ceramics of desired composition
- Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent
- Artifact level produced by different femoral head prostheses in CT imaging: diamond coated silicon nitride as total hip replacement material
- Peptide immobilization on polyethylene terephthalate surfaces to study specific endothelial cell adhesion, spreading and migration
- In vitro and in vivo evaluation of the effects of demineralized bone matrix or calcium sulfate addition to polycaprolactone–bioglass composites
- Osteoblast attachment to hydroxyapatite micro-tube scaffolds
- Hydrolysis of monetite/chitosan composites in α-MEM and SBF solutions
- Apatite-forming PEEK with TiO 2 surface layer coating
- Surface silver-doping of biocompatible glass to induce antibacterial properties. Part I: massive glass
- Long-term in vivo experimental investigations on magnesium doped hydroxyapatite bone substitutes
- Comparison of two polymeric carrier formulations for controlled release of hydrophilic and hydrophobic drugs
- Topographically induced self-deformation of the nuclei of cells: dependence on cell type and proposed mechanisms
- Monitoring cellular behaviour using Raman spectroscopy for tissue engineering and regenerative medicine applications
- Cellulose film regenerated from Styela clava tunics have biodegradability, toxicity and biocompatibility in the skin of SD rats
- Preparation, in vitro and in vivo evaluation of mPEG-PLGA nanoparticles co-loaded with syringopicroside and hydroxytyrosol
- Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel
- Self-dissolving micropile array tips for percutaneous administration of insulin
- Dental casting alloys behaviour during power toothbrushing with toothpastes with various abrasivities. Part I: wear behavior
- Fabrication, chemical composition change and phase evolution of biomorphic hydroxyapatite
- Methotrexate-grafted-oligochitosan micelles as drug carriers: synthesis and biological evaluations
- Influence of light polymerization modes on degree of conversion and crosslink density of dental composites
- Equilibrium and non-equilibrium charge-dependent quantification of endothelial cell hydrogel scaffolds
- Microstructure and wear properties of LENS ® deposited medical grade CoCrMo
- Comparison of tensile and knot security properties of surgical sutures
- Enhanced wear and fatigue properties of Ti–6Al–4V alloy modified by plasma carburizing/CrN coating
- Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery
- Quantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix
- Fabrication of bioactive hydroxyapatite/bis-GMA based composite via three dimensional printing
- Biomechanical characterisation of a degradable magnesium-based (MgCa0.8) screw
- Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
- Surface characterization and biological properties of regular dentin, demineralized dentin, and deproteinized dentin
- Fabrication and mechanical testing of porous calcium phosphate bioceramic granules
- Novel carboxymethyl chitosan-graphene oxide hybrid particles for drug delivery
- Three-dimensional nonwoven scaffolds from a novel biodegradable poly(ester amide) for tissue engineering applications
- Regulatory biocompatibility requirements for biomaterials used in regenerative medicine
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