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Title of Journal: J Mater Sci Mater Med

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Abbravation: Journal of Materials Science: Materials in Medicine

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Springer US

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DOI

10.1001/archpsyc.57.1.21

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1573-4838

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Cellulose film regenerated from Emphasis Type="It

Authors: Sung Hwa Song Ji Eun Kim Young Ju Lee Moon Hwa Kwak Geum Yong Sung Soon Hong Kwon Hong Joo Son Hee Seob Lee Young Jin Jung Dae Youn Hwang
Publish Date: 2014/02/28
Volume: 25, Issue: 6, Pages: 1519-1530
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Abstract

Cellulose is one of the most widespread biomolecules in nature and has been exploited in various applications including scaffolding tissue engineering and tissue formation To evaluate the biocompatibility of cellulose film manufactured from Styela clava tunics SCTCF these films were implanted in Sprague–Dawley SD rats for various lengths of time after which they were subjected to mechanical and biological analyses The cellulose powders 12–268 m obtained from SCT was converted into films via casting methods without adding any additives SCTCF contained about 98  αcellulose and very low concentrations of ββcellulose Additionally the crystallinity index CrI of SCTCF was lower 1071  than that of wood pulpcellulose films WPCF 3378  After implantation for 90 days the weight loss and formation of surface corrugations were greater in SCTCF than that of WPCF while the surface roughness was significantly higher in WPCF than SCTCF However there were no differences in the number of white blood cells between SCTCF implanted rats and vehicle implanted rats The level of metabolic enzymes representing liver and kidney toxicity in the serum of SCTCF implanted rats was maintained at levels consistent with vehicle implanted rats Moreover no significant alteration of the epidermal hyperplasia inflammatory cell infiltration redness and edema were observed in SD rats implanted with SCTCF Taken together these results indicate that SCTCF showed good degradability and nontoxicity without inducing an immune response in SD rats Further the data presented here constitute strong evidence that SCTCF has the potential for use as a powerful biomaterial for medical applications including stitching fiber wound dressing scaffolding absorbable hemostats and hemodialysis membrane

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