Authors: Nophawan Paradee Anuvat Sirivat Sumonman Niamlang Walaiporn PrissanaroonOuajai
Publish Date: 2012/02/22
Volume: 23, Issue: 4, Pages: 999-1010
Abstract
The drug release characteristics of calcium alginate hydrogels CaAlg under an electric field assisted transdermal drug delivery system were systematically investigated The CaAlg hydrogels were prepared by the solutioncasting using CaCl2 as a crosslinking agent The diffusion coefficients and the release mechanism of the anionic model drugs benzoic acid and tannic acid and a cationic model drug folic acid on the CaAlg hydrogels were determined and investigated using a modified FranzDiffusion cell in an MES buffer solution of pH 55 at a temperature of 37°C for 48 h The influences of the crosslinking ratio —the mole of the crosslinking agent to the mole of the alginate monomer—mesh size model drug size drug charge electric field strength and electrode polarity were systematically studied The drug diffusion coefficient decreased with an increasing crosslinking ratio and drug size for all of the model drugs The drug diffusion coefficient is precisely controlled by an applied electric field and the electrode polarity depending on the drug charge suitable for a tailormade transdermal drug delivery systemThe authors wish to express their thanks for the financial support provided by the Thailand Research Fund RGJ PHD/0285/2551 and BRG the Conductive and Electroactive Polymer Research Unit of Chulalongkorn University the Royal Thai Government and the Petroleum Petrochemical and Advanced Materials Consortium
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