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Title of Journal: J Mater Sci Mater Med

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Abbravation: Journal of Materials Science: Materials in Medicine

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Springer US

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DOI

10.1016/0769-2625(81)90008-8

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1573-4838

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Mesoporous silica nanoparticlefunctionalized poly

Authors: ShouCang Shen Wai Kiong Ng Zhilong Shi Leonard Chia Koon Gee Neoh Reginald Beng Hee Tan
Publish Date: 2011/07/24
Volume: 22, Issue: 10, Pages: 2283-
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Abstract

Polymethyl methacrylatebased bone cements are functionalized with mesoporous silica nanoparticles MSN to enable a highly efficient and sustained release of antibiotics to reduce the risk of postoperative joint infection To overcome the limited drug release of 5 for only 1 day with the current commercialgrade bone cements a 8 wt MSNformulated bone cement is able to increase the drug release efficiency by 14fold and sustain the release for up to 80 days The loaded MSN is suggested to build up an effective network of rodshaped silica particles with uniformly arranged nanoporous channels which is responsible for the effective drug diffusion and extend timerelease to the external surfaces MSN has no detrimental effect on the critical weightbearing bending modulus and compression strength of bone cement In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSNformulated bone cement

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