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Title of Journal: J Mater Sci Mater Med

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Abbravation: Journal of Materials Science: Materials in Medicine

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Springer US

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DOI

10.1007/s11187-010-9292-5

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1573-4838

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Comparison of two polymeric carrier formulations f

Authors: Haiyan Chen Yueqing Gu Yuzhu Hu
Publish Date: 2007/07/10
Volume: 19, Issue: 2, Pages: 651-658
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Abstract

Two temperature sensitive drug carriers poly Nisopropylacrylamidecoacrylic acid PNIPAcoAA and poly Nisopropylacrylamidevinyl pyrrolidoneacrylic acid PNIPAVPAA were successfully synthesized through free radical mechanism The diameters of PNIPAcoAA and PNIPAVPAA particles can be regulated to be less than 100 nm which were related to surfactant sodiumdodecyl sulfate and initiator ferrous ammonium sulfate respectively The lower critical solution temperature LCST of them can be manipulated to be higher than 40 °C which was correlated to amount of acrylic acid AA that was copolymerized with NIPA Hydrophilic antitumor drugs 5fluorouracil 5Fu and hydrophobic drug thalidomide were entrapped into PNIPAcoAA and PNIPAVPAA respectively For different interaction mechanism between drug and carrier 5Fu was prone to be entrapped in PNIPAcoAA with loading efficiency larger than 10 w/w while thalidomide was entrapped in PNIPAVPAA up to 80 w/w Fluorescein an angiography agent was used to evaluate the drug loading mechanism between PNIPAVPAA and poor watersoluble drug In vitro drug release behavior from these two drug carriers were significantly different and showed temperature dependent which demonstrated that PNIPAcoAA and PNIPAVPAA are promising candidates for different controlled drug delivery system


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  2. Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone
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  4. Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair
  5. Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds
  6. The impact of the RGD peptide on osteoblast adhesion and spreading on zinc-substituted hydroxyapatite surface
  7. Nano-hydroxyapatite/poly( l -lactic acid) composite synthesized by a modified in situ precipitation: preparation and properties
  8. Poly ( d , l -lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation
  9. Bone-like apatite coating on Mg-PSZ/Al 2 O 3 composites using bioactive systems
  10. Using chondroitin sulfate to improve the viability and biosynthesis of chondrocytes encapsulated in interpenetrating network (IPN) hydrogels of agarose and poly(ethylene glycol) diacrylate
  11. The preparation, cytocompatibility, and in vitro biodegradation study of pure β-TCP on magnesium
  12. Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics
  13. Preparation and characterization of biphasic calcium phosphate ceramics of desired composition
  14. Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent
  15. Artifact level produced by different femoral head prostheses in CT imaging: diamond coated silicon nitride as total hip replacement material
  16. Peptide immobilization on polyethylene terephthalate surfaces to study specific endothelial cell adhesion, spreading and migration
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