Authors: XiaoMei Wu Wei Sun JiaYing Xin ChunGu Xia
Publish Date: 2008/04/30
Volume: 24, Issue: 11, Pages: 2421-2424
Abstract
The lipasecatalysed kinetic resolution of secondary alcohols was studied using vinyl acetate as acyl donor in propylene carbonate Propylene carbonate offers an environmentally friendly alternative in contrast to conventional solvents Several different lipases were investigated and Candida antarctica lipase B CALB exhibited better results for all the substrates It was shown that the addition of nonreactive base triethylamine and silver oxide to the reaction mixture enhanced the reaction rate and enantioselectivity With propylene carbonate as solvent CALB could be recycled without significant activity or enantioselectivity losses
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