Authors: Francisco S Lozano José M Rodríguez Francisco J GarcíaCriado Jose R GonzalezPorras Fermin M SanchezGuijo Pilar SanchezConde Jose E GarcíaSanchez
Publish Date: 2008/01/19
Volume: 32, Issue: 4, Pages: 642-647
Abstract
The aim of this study was to design an aggressive nonlethal animal model that would simulate surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response Fourteen pigs were subjected to two sequential experiments Experiment A was performed to determine the response to two degrees of hemorrhage A1 40 bleeding and A2 60 bleeding over 15 minutes followed by midline laparotomy and aortic dissection Experiment B included two methods of aortic repair B1 aortic resection and replacement with a prosthesis and B2 aortic bypass without aortic resection In the latter two groups suprarenal aortic crossclamping was placed for 30 minutes after a 40 hemorrhage We analyzed various inflammatory markers and mortality The 40 bleeding vs 60 elicited a smaller decrease in mean arterial pressure 110 ± 6 vs 89 ± 9 mmHg but did not cause irreversible shock or mortality After the 40 hemorrhage the B1 aortic repair caused two cases of paraplegia We have developed a model to study the combined effect of bleeding and aortic crossclamping
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