Authors: Amber L Traugott Farrokh Dehdashti Kathryn Trinkaus Mark Cohen Elizabeth Fialkowski Frank Quayle Hameda Hussain Rosa Davila Lourdes Ylagan Jeffrey F Moley
Publish Date: 2010/02/06
Volume: 34, Issue: 6, Pages: 1247-1253
Abstract
In all 20 of fineneedle aspiration FNA biopsies of thyroid nodules have an indeterminate diagnosis of these 80 are found to be benign after thyroidectomy Some previous reports indicate that positron emission tomography PET with 18Ffluorodeoxyglucose FDG imaging may predict malignancy status We now report results on the first 51 patients in the largest prospective study of FDGPET in patients with an indeterminate thyroid nodule FNAEligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography and indeterminate histology of the FNA biopsy specimen Participants underwent preoperative neck FDGPET alone or FDGPET with computed tomography FDGPET/CT Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value SUVmax Final diagnosis was determined by histopathologic analysis after thyroidectomy Descriptive statistical analysis was performedA total of 51 patients underwent preoperative FDGPET or FDGPET/CT Studies without focally increased uptake localized to the lesion were considered negative For all lesions 10 malignant 41 benign the sensitivity specificity positivepredictive value PPV and negativepredictive value NPV were 80 61 33 and 93 respectively Postoperatively two malignant and six benign lesions were found to be 1 cm by pathology examination one lesion was not measured When these lesions were excluded the sensitivity specificity PPV and NPV were 100 59 36 and 100 respectivelyThis material is based on work supported in part by the Department of Veterans Affairs Veterans Health Administration Office of Research and Development through a Veterans Administration Merit Review Grant no 060309 to JFM Additional funding was provided by a BarnesJewish Hospital Foundation grant
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