Authors: Gang Chen Zhou Wang Xiangyan Liu Fanying Liu
Publish Date: 2010/10/29
Volume: 35, Issue: 1, Pages: 56-61
Abstract
The brain metastatic tumors and lung cancer tissues from 32 patients with solitary brain metastasis of nonsmall cell lung cancer M1 group who underwent combined surgical treatment from January 1998 to June 2008 and 32 paired patients without distant metastasis M0 group and 30 patients with primary brain tumor were examined by immunohistochemistry to detect the expression of CXCR4 protein The difference of CXCR4 expression was compared by the McNemar χ2 test or Fisher’s exact test Estimation of survival was calculated with the Kaplan–Meier method and the statistical differences were analyzed with the logrank testOverexpression of CXCR4 protein was observed in 29 906 M1 nonsmall cell lung cancers and in all 100 brain metastatic tumors which was significantly higher than that in the paired M0 nonsmall cell lung cancer and the primary brain tumors respectively p = 0000 The 3 and 5year cumulative survival rates of patients with solitary brain metastasis of lung cancer were 219 and 125 significantly lower than the corresponding survival rates of M0 group patients p = 0005
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