Authors: Jacopo Viganò Emanuele Cereda Riccardo Caccialanza Roberta Carini Barbara Cameletti Marcello Spampinato Paolo Dionigi
Publish Date: 2012/04/07
Volume: 36, Issue: 8, Pages: 1738-1743
Abstract
The study was designed as a controlled prospective cohort study including 38 patients treated with OCH 800 mL the day before surgery and 400 mL within 3 h before the induction of anesthesia and 38 controls matched for surgical procedure Fasting glucose insulin insulin resistance HOMAIR index cortisol and interleukin 6 IL6 were assessed before and after surgery postoperative day POD 1 2 and 3The administration of OCH resulted in lower fasting glucose HOMAIR index cortisol and IL6 on both POD 1 and POD 2 At multivariable regression analyses the reduction of these parameters was independent of sex age body mass index and major abdominal surgery Particularly models including OCH treatment explained 70 63 and 66 of the variance of the increase in IL6 levels at POD 1 POD 2 and POD 3 respectively The effect of OCH on changes in glucose insulin resistance and cortisol on POD 1 and POD 2 disappeared after the inclusion of IL6 in the models
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