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Title of Journal: Neurol Sci

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Abbravation: Neurological Sciences

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Springer Milan

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DOI

10.1007/BFb0118256

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1590-3478

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Role of matrix metalloproteinase9 in apoptosis of

Authors: Zongduo Guo Xiaochuan Sun Zhaohui He Yong Jiang Xiaodong Zhang
Publish Date: 2009/12/24
Volume: 31, Issue: 2, Pages: 143-149
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Abstract

This study investigated the possible involvement of matrix metalloproteinase 9 MMP9 in early brain injury EBI of subarachnoid hemorrhage SAH in rats MMP9 activities in hippocampus were examined at 6 12 24 48 and 72 h after SAH Laminin was detected by immunohistochemistry Apoptosis of neurons in hippocampus was observed by TUNEL Brain water content was also examined MMP9 activity and the number of apoptotic neurons increased from 12 to 72 h with a peak at 24 h Laminin was found to decrease at 12 h reached minimum at 24 h and began to increase from 48 h which had a negative correlation with apoptotic neurons The changes of brain water content were found to be coincidence with that of neuronal apoptosis Our findings suggest that MMP9 is probably involved in the pathophysiological events of EBI after SAH through degrading laminin which leads to neuronal anoikis of hippocampusThis research was supported in part by the Foundation for Excellent Doctoral Dissertation of Chongqing Medical University 0200101174 The authors are appreciative of John H Zhang from Loma Linda University Medical Centre for his helpful discussions in conducting this study

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