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Title of Journal: Neurol Sci

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Abbravation: Neurological Sciences

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Springer Milan

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DOI

10.1002/phbl.19490050111

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1590-3478

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Serum prolidase activity and oxidative status in p

Authors: Ertugrul Uzar Yusuf Tamam Osman Evliyaoglu Alpaslan Tuzcu Coskun Beyaz Abdullah Acar Birsen Aydın Nebahat Tasdemir
Publish Date: 2011/11/27
Volume: 33, Issue: 4, Pages: 875-880
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Abstract

We found no data in the literature related to oxidative stress index OSI total oxidative status TOS and prolidase activity in patients with diabetic neuropathy DN In this study we aimed to evaluate the oxidative status of DN patients via measurement of TOS and serum total antioxidant status TAS and estimation of OSI using new automated methods Thirtyeight healthy participants 40 diabetic patients without neuropathy and 39 patients with DN were included Electrophysiological and neurological examinations were performed The activity of prolidase and levels of TOS and TAS were determined in the serum of patients The level of TAS was lower while the levels of TOS and OSI and activity of prolidase were higher in both DN and diabetic control groups compared with the healthy subjects p  005 Prolidase activity was found to be higher in the DN group than in the diabetic control group p = 0001 In conclusion the presence of high TOS and OSI levels together with low levels of TAS in diabetic patients with or without neuropathy may support a role of oxidative stress in the pathogenesis of diabetes mellitus In addition increased serum prolidase activity in DN may be interpreted as evidence of increased collagen turnover

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