Authors: Luca Errichiello Pasquale Striano Diana Galletta Salvatore Striano
Publish Date: 2013/10/12
Volume: 35, Issue: 3, Pages: 469-471
Abstract
Hypothalamic hamartomas HHs are developmental nonneoplastic malformations involving the small hypothalamic area located between the infundibular stalk and the mamillary bodies 1 A spectrum of clinical conditions can be envisaged A earlyonset of laughter epileptic seizures gelastic seizures GS in previously normal children evolving toward catastrophic generalized epilepsy with cognitive regression and severe behavioral problems with or without precocious puberty B GS evolving toward severe focal epilepsy with cognitive and behavioral disturbances of various severity C late infancy onset GS evolving toward severe focal epilepsy with little or without associated cognitive and behavioral signs 1 Cognitive 2 and behavioral 3 4 5 problems have been reported and they seem to be responsive to surgical treatment 6 Although several studies assessed a high prevalence of psychiatric disorders among patients with HH 4 6 7 8 rate and specificity of
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