Authors: Naoto Sugeno Norihiko Kawaguchi Takafumi Hasegawa Takashi Kuroda Ichiro Nakashima Takashi Kanbayashi Susumu Kusunoki Masashi Aoki
Publish Date: 2012/03/15
Volume: 33, Issue: 6, Pages: 1473-1476
Abstract
Galactocerebroside GalC is a major myelin component in the central nervous system The antiGalC antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasmaassociated encephalitis Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness Brain MRI suggested that hypothalamic involvement was compatible with hypersomnia This finding was corroborated by decreased hypocretin1 in cerebrospinal fluid CSF and the manifestation of diabetes insipidus Screening for antiglycolipid antibody profiles showed the selective increase of serum antiGalC antibody After treatment with minocyclin the patient’s daytime sleepiness was markedly improved and the CSF hypocretin1 level became almost normal as well It is known that CSF hypocretin1 is decreased in GuillainBarré syndrome mediated by antiglycolipid antibody suggesting a possible mechanistic link between antiglycolipid antibodies and hypothalamic involvement The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection
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