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Title of Journal: Neurol Sci

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Abbravation: Neurological Sciences

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Springer Milan

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DOI

10.1002/ange.200805608

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1590-3478

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Chordoid meningioma a retrospective series of sev

Authors: Emiliano Passacantilli Gennaro Lapadula Federico Caporlingua Jacopo Lenzi Manila Antonelli Francesca Santoro Antonio Santoro
Publish Date: 2013/04/18
Volume: 34, Issue: 11, Pages: 1985-1989
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Abstract

Chordoid meningioma is a rare variant of meningioma characterized by a more aggressive behavior The present study documents the histological radiological and clinical features of seven cases treated at the Policlinico Umberto I of Rome from 1999 to 2010 There were five males and two females Most of the cases were located in the supratentorial space especially the convexity Surgical gross total resection was achieved in four cases Of the remaining three cases two relapsed and underwent further surgeries and adjuvant treatment The MIB1 index had a mean value of 75 range 03–258 Tumors were composed of epithelioid cells or plump to spindle cells forming cords cribriforms or nests in a mucoid matrix All tumors showed diffuse positive immunoreactivity to vimentin and epithelial membrane antigen Surgery is the first line of treatment for this kind of lesion Gross total resection guaranteed a survival free from recurrences in our series On the other hand radiation therapy must be considered in patients submitted to a subtotal resection

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