Authors: Monica Ricci Martina Pigliautile Valeria D’Ambrosio Sara Ercolani Cinzia Bianchini Carmelinda Ruggiero Nicola Vanacore Patrizia Mecocci
Publish Date: 2016/02/10
Volume: 37, Issue: 6, Pages: 867-873
Abstract
many studies sustained that the clock drawing test CDT was not able to accurately detect people with CDR = 05 Other researchers have promoted the use of scoring approaches with multiple scales that rate quantitative and qualitative features of the production Nevertheless these scoring systems are complex and timeconsuming We propose a new brief CDT’ scoring system in order to find a good measure for mild cognitive decline which is at the same time easy to administer we enrolled 719 subjects n 181 with mild Alzheimer’s disease AD n 200 with amnesic mild cognitive impairment MCI and n 338 healthy elderly subjects C our CDTthreecluster scoring system demonstrated a good sensitivity and an excellent specificity to discriminate MCI subjects from normal elderly 76 and 84 respectively and an excellent sensitivity and specificity to discriminate patients affected by mild Alzheimer disease CDR 1 from normal elderly 91 and 90 respectively We found that CDT’ score = 130 discriminate people with MCI whereas a score = 438 discriminate AD patients The threeclusterscoringsystem demonstrated a good diagnostic accuracy taking into account those erroritems more predictive of cognitive decline omission of numbers or hands writing numbers or hands in a wrong position and writing numbers or hands in a different code Our CDT’ scoring system is very short and easy method which can be used also by nonspecialist
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