Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Neurol Sci

Search In Journal Title:

Abbravation: Neurological Sciences

Search In Journal Abbravation:

Publisher

Springer Milan

Search In Publisher:

DOI

10.1002/jcc.21374

Search In DOI:

ISSN

1590-3478

Search In ISSN:
Search In Title Of Papers:

αSynuclein in the colon and premotor markers of P

Authors: JoongSeok Kim InSeok Park HyungEun Park SuYoung Kim Jung A Yun Chan Kwon Jung HyeYoung Sung JinKwon Lee WonKyung Kang
Publish Date: 2016/11/01
Volume: 38, Issue: 1, Pages: 171-179
PDF Link

Abstract

Extranigral nonmotor signs precede the first motor manifestations of Parkinson’s disease by many years in some patients The presence of αsynuclein deposition within colon tissues in patients with Parkinson’s disease can aid in identifying early neuropathological changes prior to disease onset In the present study we evaluated the roles of nonmotor symptoms and signs and imaging biomarkers of nigral neuronal changes and αsynuclein accumulation in the colon Twelve subjects undergoing colectomy for primary colon cancer were recruited for this study Immunohistochemical staining for αsynuclein in normal and phosphorylated forms was performed in normally appearing colonic tissue We evaluated 16 candidate premotor risk factors in this study cohort Among them ten subjects showed positive immunostaining with normal and phosphorylatedαsynuclein An accumulation of premotor markers in each subject was accompanied with positive normal and phosphorylatedαsynuclein immunostaining ranging from 2 to 7 markers per subject whereas the absence of Lewy bodies in the colon was associated with relative low numbers of premotor signs A principal component analysis and a cluster analysis of these premotor markers suggest that urinary symptoms were commonly clustered with deposition of peripheral phosphorylatedαsynuclein Among other premotor marker color vision abnormalities were related to nonsmoking This mathematical approach confirmed the clustering of premotor markers in preclinical stage of Parkinson’s disease This is the first report showing that αsynuclein in the colon and other premotor markers are related to each other in neurologically normal subjects

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Increasing incidence of multiple sclerosis among women in Buenos Aires: a 22 year health maintenance organization based study
  2. Motor outcomes in patients with advanced Parkinson’s disease treated with levodopa/carbidopa intestinal gel in Italy: an interim analysis from the GREENFIELD observational study
  3. Confusional state as first symptom of HaNDL syndrome
  4. Deep brain stimulation of the globus pallidus internal improves symptoms of chorea-acanthocytosis
  5. Terminal latency abnormality in amyotrophic lateral sclerosis without split hand syndrome
  6. The higher prevalence of non-right handers among patients with restless leg syndrome
  7. Neuromyelitis optica: atipic clinic presentation
  8. Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage
  9. Intravascular lymphomatosis and intracerebral haemorrhage
  10. Neurophysiological analysis of the cauda equina in POEMS syndrome
  11. How does the neck flexion affect the cervical MRI features of Hirayama disease?
  12. A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting secondary hypersomnia
  13. Serum prolidase activity and oxidative status in patients with diabetic neuropathy
  14. Can triptans safely be used for airplane headache?
  15. Multiple cranial nerve involvement in Bannwarth’s syndrome
  16. Role of neurostimulation in migraine
  17. Neuroprotective effect of apigenin in rats after contusive spinal cord injury
  18. Cranial Ewing’s sarcoma in children
  19. Comparisons of presentations and outcomes of neuromyelitis optica patients with and without Sjögren’s syndrome
  20. Chordoid meningioma: a retrospective series of seven consecutive cases
  21. Prevalence of headache in patients with Parkinson’s disease and its association with the side of motor symptom onset
  22. Dexamethasone suppression test, melatonin and TRH-test in cluster headache
  23. Post-natalizumab clinical and radiological findings in a cohort of multiple sclerosis patients: 12-month follow-up
  24. Anxiety state affects information processing speed in patients with multiple sclerosis
  25. Assessing executive function with the D-KEFS sorting test: normative data for a sample of the Italian adult population
  26. Psychiatric features in gelastic epilepsy and hypothalamic hamartoma: long-term psychodiagnostic observations
  27. Acute disseminated encephalomyelitis
  28. Induced neural stem cells have protective effects on cortical neuronal cells in vitro
  29. Clinical markers of therapeutic response to disease modifying drugs
  30. Striopallidodentate calcifications: nosographic, neuropathological and clinical proposal. Case report
  31. Major motor-functional determinants associated with poor self-reported health-related quality of life in myasthenia gravis patients
  32. Lambert-Eaton Myasthenic Syndrome presenting with a “dropped head syndrome” and associated with antibodies against N-type calcium channels
  33. Do the quantitative relationships of synaptic junctions and terminals in the thalamus of genetic absence epilepsy rats from Strasbourg (GAERS) differ from those in normal control Wistar rats
  34. Fatal Aspergillus brain abscess in immunocompetent patient
  35. The therapeutic future in headache
  36. Vitamin A and amygdala: functional and morphological consequences
  37. Carcinoma of the tongue and bulbar-onset amyotrophic lateral sclerosis: unusual differential diagnosis
  38. Effect of ACE inhibitors and AT 1 receptor antagonists on pentylenetetrazole-induced convulsions in mice
  39. The first Italian family with evidence of pyramidal impairment as phenotypic manifestation of Silver syndrome BSCL2 gene mutation
  40. Message from the Editor in Chief
  41. RETRACTED ARTICLE: Headaches and brain tumors
  42. Intestinal levodopa infusion: the Belgian experience
  43. Contact heat-evoked potentials as a useful means in patients with Guillain–Barré syndrome
  44. Contact heat-evoked potentials as a useful means in patients with Guillain–Barré syndrome
  45. The medial plantar and medial peroneal cutaneous nerve conduction studies for diabetic polyneuropathy
  46. Neurological pictures in Paediatric Chiari I malformation
  47. Contrast extravasation through MRI precedes cerebral hemorrhage in a patient with eclampsia
  48. Delayed posterior fossa epidural hematoma originating from occipital artery after infratentorial craniotomy
  49. The clock drawing test as a screening tool in mild cognitive impairment and very mild dementia: a new brief method of scoring and normative data in the elderly
  50. Neuropsychological assessment in myasthenia gravis
  51. Familial cerebral cavernous malformation: report of a further Italian family
  52. Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study
  53. Non-pharmacological management of migraine during pregnancy
  54. Cholinergic balance in dementia with Lewy bodies: reversible worsening of Parkinsonism at rivastigmine dosage modulation
  55. Chronic cerebro-spinal venous insufficiency (CCSVI) and multiple sclerosis
  56. The combined treatment with orbital and pretarsal botulinum toxin injections in the management of poorly responsive blepharospasm
  57. Reversibility of brain lesions in a case of Neuro-Behçet’s disease studied by MR diffusion
  58. Speckled lentiginous nevus: sometimes, but not always, part of a syndrome
  59. Intracranial extraaxial ependymoma in children: a rare case report and review of the literature
  60. Tension-type headache in Parma’s adult general population: a focus on age of onset
  61. Pathological gambling plus hypersexuality in restless legs syndrome: a new case
  62. Headache with transient neurological deficit: a case report with hemispheric hypoperfusion and without lymphocytosis
Search Result: