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Title of Journal: Neuroradiology

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Abbravation: Neuroradiology

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Springer-Verlag

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10.1002/chin.201338096

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1432-1920

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Presence of a central vein within white matter les

Authors: Nina Lummel Tobias BoeckhBehrens Veronika Schoepf Michael Burke Hartmut Brückmann Jennifer Linn
Publish Date: 2010/06/29
Volume: 53, Issue: 5, Pages: 311-317
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Abstract

Susceptibility weighted imaging depicts the perivenous extent of multiple sclerosis white matter lesions MSWML in vivo by directly visualizing their centrally running vein The aim of this study was to investigate the specificity of this finding for MSFifteen patients with MS and 15 patients with microangiopathic white matter lesions mWML underwent 3T MRI including a fluidattenuated inversion recovery sequence FLAIR and a susceptibility weighted angiography SWAN All WMLs were identified on FLAIR and assigned to one of the following localizations supratentorial peripheral supratentorial periventricular or infratentorial Subsequently the presence of a central vein within these lesions was assessed on SWANA total of 711 MSWMLs and 1119 mWMLs were identified on FLAIR all of which could also be visualized on SWAN A central vein was detectable in 80 of the MSWMLs and in 78 of the mWMLs in 73 and 76 of the peripheral in 92 and 94 of the periventricular and in 71 and 75 of the infratentorial MSWMLs and mWMLs respectively With regard to the supratentorial peripheral lesions significantly more mWMLs showed a central vein compared to the MSWMLs For the other localizations there was no significant difference between the groups with regard to the percentage of lesions with central vein

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