Authors: Andrés Server Bjørn A Graff Tone E Døli Orheim Till Schellhorn Roger Josefsen Øystein B Gadmar Per H Nakstad
Publish Date: 2010/09/21
Volume: 53, Issue: 6, Pages: 435-447
Abstract
To assess the diagnostic accuracy of microvascular leakage MVL cerebral blood volume CBV and blood flow CBF values derived from dynamic susceptibilityweighted contrastenhanced perfusion MR imaging DSCMR imaging for grading of cerebral glial tumors and to estimate the correlation between vascular permeability/perfusion parameters and tumor gradesA prospective study of 79 patients with cerebral glial tumors underwent DSCMR imaging Normalized relative CBV rCBV and relative CBF rCBF from tumoral rCBVt and rCBFt perienhancing region rCBVe and rCBFe and the value in the tumor divided by the value in the perienhancing region rCBVt/e and rCBFt/e as well as MVL expressed as the leakage coefficient K 2 were calculated Hemodynamic variables and tumor grades were analyzed statistically and with Pearson correlations Receiver operating characteristic ROC curve analyses were also performed for each of the variablesThe differences in rCBVt and the maximum MVL MVLmax values were statistically significant among all tumor grades Correlation analysis using Pearson was as follows rCBVt and tumor grade r = 0774 rCBFt and tumor grade r = 0417 MVLmax and tumor grade r = 0559 MVLmax and rCBVt r = 0440 MVLmax and rCBFt r = 0192 and rCBVt and rCBFt r = 0605 According to ROC analyses for distinguishing tumor grade rCBVt showed the largest areas under ROC curve AUC except for grade III from IV
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