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Title of Journal: Neuroradiology

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Abbravation: Neuroradiology

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Springer Berlin Heidelberg

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DOI

10.1016/0021-9169(93)90013-o

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1432-1920

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Microstructural white matter abnormalities in typ

Authors: Xin Tan Peng Fang Jie An Huan Lin Yi Liang Wen Shen Xi Leng Chi Zhang Yanting Zheng Shijun Qiu
Publish Date: 2016/10/25
Volume: 58, Issue: 12, Pages: 1209-1216
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Abstract

Patients with type 2 diabetes mellitus T2DM have usually been found cognitive impairment associated with brain white matter WM abnormalities However findings have varied across studies and any potential relationship with Alzheimer’s disease AD remains unclear The aim of this study was to assess the wholebrain WM integrity of T2DM patients and to compare our findings with those of published AD casesIn our study significantly decreasing FA and increasing MD and DA values P005 were found in some WM regions closely related to the default mode network DMN including cingulum the right frontal lobe involving the right uncinate fasciculus UF bilateral parietal lobes involving the superior longitudinal fasciculus SLF and the inferior longitudinal fasciculus ILF and the right middle temporal gyrus MTG involving the UF and the ILF We also found abnormalities in the thalamus involving the fornix FX anterior thalamic radiation ATR and posterior thalamic radiation PTR The damaged regions above are similar to those found in patients with AD as reported in previous studies

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