Authors: Long Chen Gavin Elias Marina P Yostos Bojan Stimec Jean Fasel Kieran Murphy
Publish Date: 2014/11/16
Volume: 57, Issue: 2, Pages: 139-147
Abstract
Cerebrospinal fluid CSF absorption has long been held to predominantly entail drainage into the venous outflow system via the intracranial arachnoid granulations Newer data suggest pathways involving spinal arachnoid granulations and lymphatic channels may also make substantial contributions to CSF outflowCSF is absorbed and drained in bulk not just through cerebral arachnoid granulations CAG but also through spinal arachnoid granulations SAG and a lymphatic pathway involving egress through cranial and spinal nerve sheaths The proportions of CSF that efflux through each of these major pathways have yet to be determined with any certainty in humans though existing evidence the majority of which is derived from animal studies suggests that lymphatic pathways may account for up to 50 of CSF outflow—presumably leaving the CAG and SAG to process the balance
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