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Title of Journal: Neuroradiology

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Abbravation: Neuroradiology

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Springer Berlin Heidelberg

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DOI

10.1016/j.arbres.2010.07.005

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1432-1920

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Clinical validation of synthetic brain MRI in chil

Authors: Hollie West James L Leach Blaise V Jones Marguerite Care Rupa Radhakrishnan Arnold C Merrow Enrique Alvarado Suraj D Serai
Publish Date: 2016/11/26
Volume: 59, Issue: 1, Pages: 43-50
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Abstract

The purpose of this study was to determine the diagnostic accuracy of synthetic MR sequences generated through postacquisition processing of a single sequence measuring inherent R1 R2 and PD tissue properties compared with sequences acquired conventionally as part of a routine clinical pediatric brain MR examThirtytwo patients underwent routine clinical brain MRI with conventional and synthetic sequences acquired 22 abnormal Synthetic axial T1 T2 and T2 fluid attenuation inversion recovery or proton densityweighted sequences were made to match the comparable clinical sequences Two exams for each patient were deidentified Four blinded reviewers reviewed eight patients and were asked to generate clinical reports on each exam synthetic or conventional at two different time points separated by a mean of 33 days Exams were rated for overall and specific finding agreement synthetic/conventional and compared to gold standard consensus review by two senior reviewers with knowledge of clinical report quality and diagnostic confidenceOverall agreement between conventional and synthetic exams was 97 Agreement with consensus readings was 84 conventional and 81 synthetic p = 061 There were no significant differences in sensitivity specificity or accuracy for specific imaging findings involving the ventricles CSF brain parenchyma or vasculature between synthetic or conventional exams p  005 No significant difference in exam quality diagnostic confidence or noise/artifacts was noted comparing studies with synthetic or conventional sequencesWe declare that all human and animal studies have been approved by the institutional review board and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments We declare that all patients gave informed consent prior to inclusion in this study

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