Authors: Paul Urbain Anna Raynor Hartmut Bertz Christine Lambert HansKonrad Biesalski
Publish Date: 2011/10/01
Volume: 20, Issue: 8, Pages: 1831-1838
Abstract
The primary objective of this prospective study was to investigate the association between the incidence and severity of OM WHO oral toxicity scale and the AOX status in buccal mucosa cells BMC and plasma The αtocopherol ascorbic acid and ßcarotene concentrations in BMC and plasma were assessed at admission in 70 patients with a median age of 58 years before undergoing allogeneic HCTSevere OM III–IV ulcerative OM II–IV and no or mild OM 0–I were documented in 14 200 32 457 and 38 543 patients respectively We observed no significant differences in baseline AOX concentrations in plasma or BMC among the OM groups However between patients with at least one plasma AOX beneath the normal range 39/70 and those with all plasma AOX in the normal range 31/70 we noted a trend towards longer duration of parenteral nutrition PN during the study period 10 vs 8 days p = 0066No single AOX either in plasma or BMC αtocopherol ascorbic acid and ßcarotene revealed predictive value for the incidence or severity of OM However patients with an overall good plasma AOX status tended to require less PN a common clinical marker for OM which may be more relevant than any one AOX at reducing the risk of OMWe are grateful to Carole Cürten for proofreading this manuscript to Gabriele Ihorst from the Institute of Medical Biometry of the AlbertLudwigs University of Freiburg for the statistical advice and to Monika Neher for data collection The authors responsibilities were as follows PU study concept and design obtaining funding statistical analysis data collection and interpretation and writing the manuscript AR statistical analysis data collection and interpretation and writing the manuscript HB supervision of the study critical review and contribution to the final draft and HKB study concept critical review and contribution to the final draft All authors have read and approved the final manuscript None of the authors expresses a conflict of interest PU was supported by the National Research Fund Luxemburg and young scientist award for financial support for material and analytics issued in 2008 by the German Society for Clinical Nutrition DGEM eV
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