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Title of Journal: Support Care Cancer

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Abbravation: Supportive Care in Cancer

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Springer Berlin Heidelberg

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DOI

10.1007/bf03282651

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ISSN

1433-7339

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Impact of antibacterial prophylaxis during reinduc

Authors: Beejal R Ganti Bernard L Marini Jerod Nagel Dale Bixby Anthony J Perissinotti
Publish Date: 2016/10/14
Volume: 25, Issue: 2, Pages: 541-547
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Abstract

This was a retrospective singlecenter cohort study Adult patients with relapsed/refractory AML admitted for reinduction chemotherapy between November 1 2006 and June 15 2015 were screened for inclusion A protocol initiating levofloxacin prophylaxis was implemented on December 1 2013 Patients receiving hypomethylating agents decitabine/azacitidine were not administered antibacterial prophylaxis and thus not included in this analysis Patients receiving broad spectrum antibiotics on day 1 of reinduction chemotherapy or receiving another antibacterial agent for prophylaxis were also excluded Ninetyseven patients were included in the control group no prophylaxis while 48 patients received levofloxacin prophylaxis Patients in the prophylaxis group received levofloxacin 500 mg once daily on day 1 of chemotherapy and continued until neutrophil recovery or hospital discharge or deathThere was a reduction in the rate of bacteremia in the prophylaxis group 375  compared to the control group 536  p = 00789 largely due to a reduction in gramnegative bacteremia 21 vs 216  respectively p = 0001 No difference was found between prophylaxis and the control groups in the incidence of neutropenic fever incidence of multidrug resistance length of hospital or ICU stay or mortalityData collection using the REDCap software was supported by the Michigan Institute for Clinical and Health Research grant CTSAULT1TR000433 We also acknowledge the University of Michigan Honest Broker Office for the assistance with data extraction from the electronic medical recordAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards For this type of study formal consent is not required and as such a waiver of informed consent was granted by the institutional review board

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