Authors: A Navigante P Cresta Morgado O Casbarien N López Delgado R Giglio M Perman
Publish Date: 2013/01/16
Volume: 21, Issue: 6, Pages: 1685-1690
Abstract
We prospectively evaluated 41 treatmentnaive cancer patients of several origins that presented with performance status 1–2 weight loss 5 in the last 6 months and Fatigue Numeral Scale score 4 Weakness was considered a physical component of the multidimensional fatigue syndrome and was evaluated through several parameters utilizing hand grip strength technique by dinamometry The same assessment was also performed on a healthy control population n = 20 BIAderived phase angle was also determined by BIACompared to healthy controls cancer patients exhibited significant differences in all the parameters median fatigue was 6 range 5–9 evaluated maximal strength mean was 27 ± 1071 vs 42 ± 1074 kg p 00001 for patients vs control respectively and muscle strength difference max–min muscle strength was also statistically different p 00001 We also determined parameter associations within the patient population We found statistical significant correlations between median phase angle score and endurance muscle with percentage of weight loss r = 043 p = 003 for head and neck cancer patients and in nonsmall cell lung cancer patients grip work correlated significantly with normal or decreased phase angle r = 085 p = 0006 Spearman Rank CorrelationWeakness could be correlated with normal or decreased phase angle in a population with ambulatory advanced cancer with fatigue naive of treatment We also found a significant relationship between median phase angle score and endurance muscle with percentage of weight loss in the subpopulation of patients with head and neck carcinoma
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