Authors: Hamza Abbas RenéJean Bensadoun
Publish Date: 2011/02/22
Volume: 20, Issue: 1, Pages: 185-190
Abstract
Patients with biopsyproven head and neck squamous cell carcinoma HNSCC treated with radical radiotherapy and weekly concurrent cisplatin 40 mg/m2 at the South Egypt Cancer Institute Assiut were randomly assigned to one of the following groups treatment group prophylactic trolamine emulsion every 8 h 4 h apart from the radiotherapy session or control group usual supportive care The primary outcome was the reduction of grade III or higher skin toxicity as per RTOG Acute Radiation Toxicity CriteriaFrom March 2008 to June 2009 30 patients were entered onto the trial The average age was 545 years Patients were predominately male 83 and most continued to use tobacco products 70 The rate of skinreaction was 100 in both groups A mild radiation reaction grades I and II occurred as follows 80 12/15 cases in the treatment group and 466 7/15 cases in the control group A grade III skin reaction developed in 20 3/15 cases in the treatment group and 533 8/15 cases in the controls There was a significant difference P 001 between the two groups
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