Authors: Wadih Rhondali Sriram Yennurajalingam Jeanette Ferrer Gary Chisholm Marilene Filbet Eduardo Bruera
Publish Date: 2013/11/16
Volume: 22, Issue: 4, Pages: 871-879
Abstract
Advanced cancer patients often experience moderate to severe physical and emotional distress One of the main components of emotional distress is depression The objective of this study was to examine the association between supportive care interventions and patient selfreported depression PSRD among advanced cancer outpatientsWe included consecutive patients seen in the outpatient Supportive Care Center between February 2008 and February 2010 with at least one followup visit We used the Edmonton Symptom Assessment Scale ESAS to assess their symptom intensity Clinical improvement of PSRD was defined as an improvement of at least 30 between the initial visit and the first followup We used logistic regression models to assess possible predictors of improvement in PSRDWe included 444 patients with a median age of 59 years Q1–Q3 51–65 The most common type of cancer was gastrointestinal 98 22 Out of the 444 patients 160 36 reported moderate/severe depression at baseline ESAS item score ≥ 4/10 Higher baseline depression intensity was significantly associated to anxiety r = 0568 p = 0046 total symptom distress score TSDS r = 0550 p 0001 and personal history of depression r = 0242 p = 0001 Of the 160 patients 90 56 with moderate/severe PSRD at baseline showed a significant improvement at the followup visit p = 0038 Improvement in anxiety sedation and feeling of wellbeing were associated with higher depression improvement OR 793 CI 374–1680 and OR 244 CI 109–546 respectivelyPreparation of this manuscript is supported in part by the MD Anderson Cancer Center support grant CA 016672 the American Cancer Society RSG1117001PCSM SY and the National Institutes of Health grants R01NR01016201A1 R01CA122229201 and R01CA12448101 EB
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