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Title of Journal: J SolGel Sci Technol

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Abbravation: Journal of Sol-Gel Science and Technology

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Springer US

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DOI

10.1016/0003-9861(61)90272-7

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1573-4846

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Sustained release drug delivery using supramolecul

Authors: Sayyed A Sajadi Tabassi Farnaz Sadat Mirzazadeh Tekie Farzin Hadizadeh Rahof Rashid Elham Khodaverdi Seyed Ahmad Mohajeri
Publish Date: 2014/01/24
Volume: 69, Issue: 1, Pages: 166-171
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Abstract

Supramolecular hydrogels SMGel have attracted much attention as a drug and gene delivery system in recent years In this study SMGels based on the triblock copolymer of polyεcaprolactone–polyethylene glycol–polyεcaprolactone PCL–PEG–PCL and αcyclodextrin αCD were prepared and evaluated for the delivery of two model drugs naltrexone hydrochloride and vitamin B12 Triblock copolymers were synthesized easily in 15 min by ringopening polymerization using the microwave irradiation technique and their structures were determined by gel permeation chromatography and nuclear magnetic resonance methods SMGels composed of various concentrations of the copolymer and αCD were prepared and characterized for their rheological behaviour their gel formation time and in vitro drug release profile The results indicated that copolymers with a PCL to PEG ratio of 14 are suitable for SMGel preparation The most viscose system with good syringeability was prepared by mixing 12  wt αCD and 10  wt of copolymer The gelation was found to occur within a minute after mixing The viscosity of the hydrogel systems was determined as a function of shear rate Finally in vitro B12 release through the hydrogel systems was studied Up to 80  of Vitamin B12 was released through this system during a period of 20 days Rheological evaluation revealed that the hydrogel has shear thinning properties and the system regained its ground rheological state in a time dependent manner Polymer concentration did not affect the drug release profiles Finally it was concluded that such systems are appropriate drug delivery systems due to their ability to provide a controlled drug release profile and their shear thinning thixotropic behaviour which makes them syringeable and injectable

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  10. Simple synthesis of Co 3 O 4 nanoflakes using a low temperature sol–gel method suitable for photodegradation of dyes
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  13. Comparison of structure and phase change characteristic of microencapsulated core/shell Al–Si alloy microparticles synthesized by two methods
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