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Publish Date: 1940/11/23
Volume: 115, Issue: 21, Pages: 1825-1826
Abstract
This book details the results of four years of research work in Copenhagen by Bruun who attempted to corroborate the animal experiments of Klinge and others on serum allergy inflammatory reactions in various tissues of animals sensitized to horse or other serum and treated with subsequent doses of the same serum Of late a number of German and American workers have supported the hypothesis that allergy somehow takes part in the causation of chronic polyarthritis as well as rheumatic fever Beginning in 1929 Klinge sensitized animals with subcutaneous injections of protein fresh horse serum and subsequently injected the antigen into knee joints of rabbits producing in joints heart muscles liver and other tissues lesions considered analogous to those of human rheumatism In the injected but not in the noninjected joints acute phlegmonous and chronic nonsuppurative arthritis were produced in heart muscle and valves lesions appeared which included some resembling Aschoff
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