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Title of Journal: JAMA

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Abbravation: Journal of the American Medical Association

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American Medical Association

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0002-9955

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PRELIMINARY CLINICAL EVALUATION OF THROMBIN RECOVE

Authors: L A Sternberger
Publish Date: 1952/12/20
Volume: 150, Issue: 16, Pages: 1591-1593
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Abstract

The laboratory diagnosis of thrombosis has been difficult because of the absence in circulating blood of the two essential products of coagulation thrombin and fibrin The fibrin is fixed at a local site while the excess of thrombin formed becomes inactivated immediately by antithrombic substances Recently a method for recovering such inactivated thrombin has been developed1 and elevated values have been demonstrated in thrombosis produced experimentally in rabbits The method has now been applied to patients and the present paper reports on these clinical observationsMETHODS  The recovery of thrombin is accomplished by dissociating the thrombinantithrombin complex with alkali slightly above freezing temperature and by preventing its reassociation upon neutralization through the addition of ethyl alcohol to a final concentration of 25 Nine milliliters of venous blood are obtained with siliconized syringes2 containing 10 ml of 4 sodium citrate solution Siliconized needles 19 gauge are used The plasma

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References

citation title=The Action of Heparin Serum Albumin Crystalline and Salmine on BloodClotting Mechanisms In Vitro citation author=Ferguson J HAm J Physiol citation year=1940 citation volume=130 citation issue=Oct citation pages=759770

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  1. A Text-Book of the Practice of Medicine.
  2. A Nutrition Program and Teaching Outline Developed for Use in the Health Centers and Clinics of the Division of Child Hygiene, Department of Public Health, Philadelphia
  3. THEORY OF SERUM THERAPY; CONTRIBUTION FROM THE BACTERIOLOGIC LABORATORY OF THE CITY OF PHILADELPHIA.
  4. THE ERYTHROCYTE SEDIMENTATION RATE: THE ADEQUACY OF A SIMPLE TEST AND ITS PRACTICAL APPLICATION IN CLINICAL MEDICINE
  5. Experimental Investigations in Serum Allergy with Reference to the Etiology of Rheumatic Joint Diseases
  6. Grayson's Diseases of the Nose, Throat and Ear. A Treatise on the Diseases of the Throat, Nose and the Associated Affections of the Ear.
  7. THE HUMIDITY OF SCHOOLROOMS
  8. THE PROPER MATERIAL FOR MEDICAL SOCIETIES.
  9. BERLIN
  10. WHAT IS FEVER?
  11. LETTER FROM PARIS.
  12. PULMONARY RESECTION FOR METASTASIS FROM CARCINOMA OF THE LUNG: REPORT OF A CASE
  13. THE STUDY OF NORMALS
  14. LONDON
  15. Ker's Manual of Fevers.
  16. TOXICITY OF METHIMAZOLE (TAPAZOLE)
  17. WHIPPLE'S DISEASE (INTESTINAL LIPODYSTROPHY) AND SERUM GLYCOPROTEINS
  18. Chirurgie De La Plevre Et Du Poumon.
  19. HYPERURICEMIA
  20. YELLOW FEVER AND MOSQUITOES.
  21. CAMP-FOLLOWERS OF SCIENCE.
  22. Medical News
  23. Elementary General Psychology
  24. THE STERILIZATION OF SURGEONS' SANITARY PAPER CAPS
  25. BACILLUS COLI SEPSIS: CLINICAL STUDY OF TWENTY-EIGHT CASES OF BLOOD STREAM INFECTION BY THE COLON BACILLUS
  26. Medical News
  27. Treatment of Incised Wounds Involving Tendons
  28. THE COST OF LIVING AND ADEQUATE NUTRITION
  29. ORGANIZATION SECTION
  30. PREVENTION OF DEFORMITIES IN CHRONIC ARTHRITIS: II. THE SPINE AND THE HEAD
  31. Rational Organotherapy, with Reference to Urosemlology.
  32. THE PROTECTION OF THE ROENTGEN RAY OPERATOR.
  33. THE HYPOPHYSEAL GONADOTROPIC HORMONES
  34. Veterinary Bacteriology
  35. QUERIES AND MINOR NOTES
  36. AN UNUSUAL TWIN BIRTH: A CASE IN WHICH THE TWO HEADS WERE BORN AT THE SAME TIME
  37. A Text-Book of General Bacteriology.
  38. NEW OCCLUDING URETERAL CATHETER AND CYSTOSCOPES FOR FUNCTIONAL RENAL TESTS
  39. RELIEF OF HAY-FEVER BY INTRADERMAL INJECTIONS OF POLLEN EXTRACT
  40. CIRCULATORY AND RESPIRATORY ADJUSTMENTS TO HEMORRHAGE
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  43. THE EXPERT AND THE ISSUE
  44. PUNISHMENT FOR VENEREAL DISEASE IN THE ARMED FORCES ENDED BY CONGRESS
  45. THE MATHEMATICAL POINT OF REVERSAL IN SKIASCOPY.
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  49. Johnson & Johnson's Digestive Tablets.
  50. DIABETIC DIETS IN GRAMS PER KILOGRAM OF BODY WEIGHT: CALCULATED FROM REPORTS ON ONE HUNDRED AND FORTY CHILDREN TREATED WITH INSULIN
  51. IMPORTANCE OF BIOLOGICAL RESEARCH IN INDUSTRIAL MEDICINE
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  57. PLIGHT OF AMERICAN INSTRUMENT MAKERS
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  64. Die Wissenschaft vom Traum: Ergebnisse und Probleme. Eine Einführung in die allgemeinen Grundlagen
  65. A Card from Secretary Atkinson.
  66. HEALTH IN THE ARMY
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  68. Current Comment
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