Authors: K H Vogelberg G Meurers
Publish Date: 1986/06/01
Volume: 64, Issue: 11, Pages: 506-511
Abstract
Severe forms of arterial occlusive diseases occurred more frequently in 11 insulintreated diabetics with persisting hyperlipidemia than in 10 control subjects who were 11 years older Triglycerides and cholesterol of total serum and of VLDL were 2–7 times higher P001 however LDLcholesterol was 2 times lower than in control subjects P0025 HDLcholesterol was not significantly different in either group After insulin administration 81 U/die vs 37 U/dieP000251 the increased lipids were only insignificantly reduced while LDLcholesterol and the ratio of LDL/HDLcholesterol was even increased P00025 andP005 In contrast to control subjects VLDLcholesterol was positively correlated to the tolbutamidinduced insulin reserve before insulin administration and to the diurnal insulin dosage after insulin administration P001 andP0001 The results show that the atherosclerotic risk in diabetics with persisting hyperlipidemia is higher than in control subjects and that the risk is distinguished by increased VLDLcholesterol in correlation with increased insulin concentrations Since the atherosclerotic risk is even more accentuated by the fact that insulin administration increases LDLcholesterol insulin therapy must be observed carefully in these patients
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