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Title of Journal: Hum Genet

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Abbravation: Human Genetics

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Springer-Verlag

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DOI

10.1016/0002-9416(76)90260-8

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1432-1203

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A genetic study of Hodgkins lymphoma an estimate

Authors: Yin Yao Shugart Kari Hemminki Pauli Vaittinen Albert Kingman Chuanhui Dong
Publish Date: 2000/04/13
Volume: 106, Issue: 5, Pages: 553-556
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Abstract

Hodgkins lymphoma HL is a heterogeneous hemopoietic malignancy Previous studies have implicated a genetic etiology responsible for familial HL We have estimated the heritability of HL and tested the hypothesis of genetic anticipation by using a high quality cancer database of the Swedish population Heritability was estimated by employing a thresholdliability model To test the hypothesis of anticipation the usual Ttest procedure was used to test whether there was a difference in cancer ageofonset between parents and children who were affected with HL A randomization test was carried out to test the validity of the Pvalues Additional analyses were performed after stratifying the data based on birth cohorts This data set revealed that there was a difference between the ageofonset of parents and of offspring who were affected with HL We also estimated the heritability of HL in the Swedish population to be approximately 284 Both findings provide further evidence for a genetic basis for HL

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