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Title of Journal: Hum Genet

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Abbravation: Human Genetics

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Springer-Verlag

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DOI

10.1016/0006-291x(83)90572-7

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1432-1203

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Polymorphisms of complement receptor 1 and interle

Authors: Swapan K Nath John B Harley Young Ho Lee
Publish Date: 2005/08/27
Volume: 118, Issue: 2, Pages: 225-
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Abstract

A number of studies have tested the association of the complement receptor 1 CR1 and Interleukin10 IL10 polymorphisms with systemic lupus erythematosus SLE but reported conflicting results The aim of the study is to explore whether the CR1 and IL10 genes are associated with SLE susceptibility We surveyed studies on the CR1 and IL10 polymorphisms and SLE using comprehensive Medline search and review of the references A metaanalysis was conducted in a fixed effects model or random effects model based on betweenstudy heterogeneity Eighteen comparisons from 13 studies were included in the CR1 metaanalysis and a total of 16 separate comparisons were used for the IL10 metaanalysis The CR1 metaanalysis showed no significant association of the CR1 functional polymorphisms with SLE In contrast the S structural variant of the CR1 showed a significant association OR=1544 95 CI 1217–1959 P0001 Stratification by ethnicity indicated that the CR1 S variant was associated with SLE in Caucasians OR=1667 95 CI 1193–2357 P=0003 The IL10 metaanalysis showed a significant association between SLE and the G11 allele of IL10G OR=1279 95 CI 1027–1593 P=0028 in whole populations and IL10 promoter −1082G allele was associated with SLE in Asians OR=1358 95 CI 1015–1816 P=0039 In conclusion the CR1 metaanalysis revealed the association of the S structural variant of the CR1 with SLE and the IL10 metaanalysis showed the association of IL10G11 allele and SLE in whole populations and the association between promoter A1082G polymorphism and SLE in Asians

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