Journal Title
Title of Journal: Hum Genet
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Abbravation: Human Genetics
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Publisher
Springer Berlin Heidelberg
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Authors: O Balanovsky M Chukhryaeva V Zaporozhchenko V Urasin M Zhabagin A Hovhannisyan A Agdzhoyan K Dibirova M Kuznetsova S Koshel E Pocheshkhova I Alborova R Skhalyakho O Utevska The Genographic Consortium Kh Mustafin L Yepiskoposyan C TylerSmith E Balanovska
Publish Date: 2017/03/09
Volume: 136, Issue: 4, Pages: 437-450
Abstract
Ychromosomal variation in West Asian populations has so far been studied in less detail than in the neighboring Europe Here we analyzed 598 Ychromosomes from two West Asian subregions—Transcaucasia and the Armenian plateau—using 40 YSNPs and 17 YSTRs and combined them with previously published data from the region The West Asian populations fell into two clusters upland populations from the Anatolian Armenian and Iranian plateaus and lowland populations from the Levant Mesopotamia and the Arabian Peninsula This geographic subdivision corresponds with the linguistic difference between IndoEuropean and Turkic speakers on the one hand and Semitic speakers on the other This subdivision could be traced back to the Neolithic epoch when upland populations from the Anatolian and Iranian plateaus carried similar haplogroup spectra but did not overlap with lowland populations from the Levant We also found that the initial gene pool of the Armenian motherland population has been well preserved in most groups of the Armenian Diaspora In view of the contribution of West Asians to the autosomal gene pool of the steppe Yamnaya archaeological culture we sequenced a large portion of the Ychromosome in haplogroup R1b samples from presentday East European steppe populations The ancient Yamnaya samples are located on the “eastern” RGG400 branch of haplogroup R1bL23 showing that the paternal descendants of the Yamnaya still live in the Pontic steppe and that the ancient Yamnaya population was not an important source of paternal lineages in presentday West EuropeansThe Genographic Consortium includes Li Jin Hui Li Shilin Li Fudan University Shanghai China Pandikumar Swamikrishnan IBM Somers New York United States Asif Javed Laxmi Parida Ajay K Royyuru IBM Yorktown Heights New York United States R John Mitchell La Trobe University Melbourne Victoria Australia Pierre A Zalloua Lebanese American University Chouran Beirut Lebanon Syama Adhikarla ArunKumar GaneshPrasad Ramasamy Pitchappan Arun Varatharajan Santhakumari Kavitha Valampuri Madurai Kamaraj University Madurai Tamil Nadu India R Spencer Wells and Miguel G Vilar National Geographic Society Washington District of Columbia United States Himla Soodyall National Health Laboratory Service Johannesburg South Africa Elena Balanovska Oleg Balanovsky Research Centre for Medical Genetics Russian Academy of Medical Sciences Moscow Russia Chris TylerSmith The Wellcome Trust Sanger Institute Hinxton United Kingdom Fabrício R Santos Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil Jaume Bertranpetit Marc Haber Marta Melé David ComasUniversitat Pompeu Fabra Barcelona Spain Christina J Adler Alan Cooper Clio S I Der Sarkissian Wolfgang Haak University of Adelaide South Australia Australia Matthew E Kaplan Nirav C Merchant University of Arizona Tucson Arizona United States Colin Renfrew University of Cambridge Cambridge United Kingdom Andrew C Clarke Elizabeth A MatisooSmith University of Otago Dunedin New Zealand Jill B Gaieski Theodore G Schurr University of Pennsylvania Philadelphia Pennsylvania United StatesAll procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Research Centre for Medical Genetics Moscow Russia and with the 1964 Helsinki declaration and its later amendments or comparable ethical standardsThis study received primary support from the Russian Science Foundation Grant 141400827 to OB MC AA VZ including data analysis and completing the paper Ychromosomal resequencing was done mainly using funding from the Historical Genetics lab in the Moscow Institute of Physics and Technology Erzurum Armenian samples were genotyped with support from the Russian Foundation for Basic Research Grant 163600122 to MC while the Hemsheni and Krasnodar Armenian samples were genotyped with support from the Russian Foundation for Basic Research Grant 160600364 to EP and from the Genographic project CTS was supported by The Wellcome Trust 098051
Keywords:
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