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Title of Journal: Hum Genet

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Abbravation: Human Genetics

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Springer Berlin Heidelberg

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DOI

10.1007/s10903-011-9542-x

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ISSN

1432-1203

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A genomewide association study of severe teenage

Authors: Mingfeng Zhang Abrar A Qureshi David J Hunter Jiali Han
Publish Date: 2013/10/11
Volume: 133, Issue: 3, Pages: 259-264
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Abstract

Despite the family aggregation of severe teenage acne the genetic basis of this common skin condition remains unclear We conducted a genomewide association study GWAS on severe teenage acne in 928 European Americans The SNP rs4133274 on chromosome 8q24 72 kb upstream of MYC revealed the most significant association with severe teenage acne p value = 17 × 10−6 The variant allele of this SNP G allele was associated with an increased risk of severe teenage acne with odds ratio of 401 95  confidence interval = 237–682 Upon further replication our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studiesWe thank Constance Chen for programming support and thank Pati Soule and Dr Hardeep Ranu of the Dana Farber/Harvard Cancer Center HighThroughput Polymorphism Detection Core for sample handling and genotyping of the NHSII samples We thank the participants in the Nurses’ Health Study II for their dedication and commitment In addition we would like to thank the participants and staff of the Nurses’ Health Study II for their valuable contributions as well as the following state cancer registries for their help AL AZ AR CA CO CT DE FL GA ID IL IN IA KY LA ME MD MA MI NE NH NJ NY NC ND OH OK OR PA RI SC TN TX VA WA and WY The NHSII cohort is supported by NIH grant CA50385 and CA67262

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