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Title of Journal: Hum Genet

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Abbravation: Human Genetics

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Springer-Verlag

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1432-1203

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Genetic analysis of adiponectin and obesity in His

Authors: Beth S Sutton Stefanie Weinert Carl D Langefeld Adrienne H Williams Joel K Campbell Mohammed F Saad Steven M Haffner Jill M Norris Donald W Bowden
Publish Date: 2005/04/21
Volume: 117, Issue: 2-3, Pages: 107-118
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Abstract

Adiponectin coded for by the APM1 gene is a novel adipocytederived hormone implicated in energy homeostasis and obesity Several genetic studies have observed evidence of association between APM1 gene polymorphisms and features of the metabolic syndrome such as insulin resistance and obesity As part of a comprehensive genetic analysis of the APM1 gene we have screened 96 unrelated individuals for polymorphisms in the promoter coding regions and 3’untranslated region UTR Three promoter singlenucleotide polymorphisms SNPs two rare coding SNPs G113A and T1233C and 13 SNPs in the 3’UTR were identified Eighteen SNPs were genotyped in 811 Hispanic individuals from 45 families in the IRAS Family Study IRASFS SNPs were tested for association with six obesity quantitative traits body mass index waist waisthip ratio subcutaneous adipose tissue visceral adipose tissue and visceralsubcutaneous ratio Significant evidence of association to at least one of the obesity traits was identified in seven of the 18 SNPs 0001–005 The promoter SNP INS CA11156 was the most consistently associated SNP and was associated significantly with all measures of obesity except the visceralsubcutaneous ratio Pvalues 0009–003 Haplotype analysis supported this evidence of association with haplotypes containing an insertion of one CA repeat at position −11156 consistently being associated with lower obesity values Pvalue 0001–005 The adiponectin polymorphisms in particular those in the promoter region thus show significant association with obesity measures in the Hispanic population Additional studies are needed to confirm our findings and determine which polymorphism causes the functional effect

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