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Title of Journal: Hum Genet

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Abbravation: Human Genetics

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Springer-Verlag

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DOI

10.1007/bf01009797

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1432-1203

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Ychromosomal DNA haplogroups and their implicatio

Authors: HanJun Jin KyoungDon Kwak Michael F Hammer Yutaka Nakahori Toshikatsu Shinka JuWon Lee Feng Jin Xuming Jia Chris TylerSmith Wook Kim
Publish Date: 2003/09/18
Volume: 114, Issue: 1, Pages: 27-35
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Abstract

We have analyzed eight Ychromosomal binary markers YAP RPS4Y711 M9 M175 LINE1 SRY+465 47z and M95 and three YSTR markers DYS390 DYS391 and DYS393 in 738 males from 11 ethnic groups in east Asia in order to study the male lineage history of Korea Haplogroup DEYAP was found at a high frequency only in Japan but was also present at low frequencies in northeast Asia including 25 in Korea suggesting a northern origin for these chromosomes Haplogroup CRPS4Y711 was present in Korea and Manchuria at moderate frequencies higher than in populations from southeast Asia but lower than those in the northeast which may imply a northern Asian expansion of these lineages perhaps from Mongolia or Siberia The major Ychromosomal expansions in east Asia were those of haplogroup OM175 and its sublineages This haplogroup is likely to have originated in southern east Asia and subsequently expanded to all of east Asia The moderate frequency of one sublineage in the Koreans haplogroup OLINE1 125 could be a result of interaction with Chinese populations The age of another sublineage haplogroup OSRY+465 and YSTR haplotype diversity provide evidence for relatively recent male migration originally from China through Korea into Japan In conclusion the distribution pattern of Ychromosomal haplogroups reveals the complex origin of the Koreans resulting from genetic contributions involving the northern Asian settlement and range expansions mostly from southerntonorthern ChinaWe thank L Roewer for providing reference YSTR DNA samples P Underhill for SNP genotyping information and DJ Shin for his helpful laboratory assistance and DNA sampling We especially thank T Karafet for useful comments on the manuscript This work was supported by a grant from the Korean Science and Engineering Foundation KOSEF F012001000200240

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