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Title of Journal: Pflugers Arch Eur J Physiol

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Abbravation: Pflügers Archiv

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Springer-Verlag

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10.1016/0021-9797(85)90132-8

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1432-2013

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Identification of a nonselective cation channel c

Authors: Hiroshi Miyoshi Kaoru Yamaoka Robert E Garfield Koso Ohama
Publish Date: 2003/10/25
Volume: 447, Issue: 4, Pages: 457-464
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Abstract

Nonselective cation channel NSCC currents were identified in myometrial smooth muscle cells isolated from pregnant rats day 18–20 using the wholecell patch clamp method NSCC currents had a linear current/voltage relationship and were time independent Reduction of extracellular Na+ substantially decreased the amplitude of NSCC currents indicating that the NSCC is permeable to Na+ NSCC currents were blocked by La3+ and Gd3+ with K d values of 22 and 10 µM respectively The relative permeability of various monovalent cations for NSCC was estimated by measurement of the reversal potential The relative permeability for K+Cs+Na+Li+ was 1310908 NSCC also had a small but detectable permeability for Ca2+ Extracellular Mg2+ inhibited myometrial NSCC currents concentration dependently with a K d of 028 mM The observed Mg2+ block may reasonably explain the inhibitory effect of magnesium on uterine contractions in the treatment of preterm labor Our results suggest that the NSCC plays a role in the regulation of myometrial contractilityWe express our sincere gratitude to Dr Stephen M Vogel Department of Pharmacology University of Illinois at Chicago College of Medicine for critical reading of the manuscript This work was supported by the Ministry of Education and Culture of Japan Grant 14571564 to HM and by a Kanzawa Medical Research Foundation Grant to HM

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