Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Pflugers Arch Eur J Physiol

Search In Journal Title:

Abbravation: Pflügers Archiv

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1002/ajpa.1330270131

Search In DOI:

ISSN

1432-2013

Search In ISSN:
Search In Title Of Papers:

KSubscriptATP/Subscript channel current increa

Authors: R Surber C Bollensdorff S Betge T Zimmer K Benndorf
Publish Date: 2006/03/02
Volume: 452, Issue: 4, Pages: 428-434
PDF Link

Abstract

Adenosintriphosphatesensitive potassium channels KATP channels are an important linkage between the metabolic state of a cell and electrophysiological membrane properties In this study KATP channels were studied in myocytes of normal and remodeled myocardium of the rat Myocardial infarction was induced by ligature of the left anterior descending artery Remodeled myocytes were obtained from the hypertrophied posterior left ventricular wall and interventricular septum 3 months after infarction The current through KATP channels was measured in wholecell and insideout patches by using the patchclamp technique After myocardial infarction the heart weight/body weight ratio was doubled and the myocytes were hypertrophied yielding a cell capacitance of 266±16 pF compared to 122±12 pF in control cells The amount of Kir62 protein was indistinguishable in corresponding regions of control and remodeled hearts The ATP sensitivity of KATP channels in remodeled cells was significantly lower than in control cells half maximum block at 115 μmol/l ATP in remodeled and at 71 μmol/l ATP in control cells The maximum I KATP density induced by metabolic inhibition was higher in small remodeled 176±15 pA/pF than in control cells 127±11 pA/pF but was unchanged in large remodeled cells Both the higher I KATP density and the lower sensitivity of the KATP channels to ATP suggest that remodeled cardiomyocytes develop an improved tolerance to ischemia by stabilizing the resting potential and decreasing excitability

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Evaluation of biomechanical status of dysplastic human hips
  2. Functional maturation of nicotinic acetylcholine receptors as an indicator of murine muscular differentiation in a new nerve-muscle co-culture system
  3. PPARγ agonists do not directly enhance basal or insulin-stimulated Na + transport via the epithelial Na + channel
  4. Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney
  5. Voltage-driven p -aminohippurate, chloride, and urate transport in porcine renal brush-border membrane vesicles
  6. Molecular physiology of EAAT anion channels
  7. Initial charge distribution and capacity transients in frog skeletal muscle
  8. How steroid hormones act on the endothelium—insights by atomic force microscopy
  9. Effects of temperature on pacemaker potentials in the mouse small intestine
  10. Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts
  11. High glucose inhibits HCO 3 − and fluid secretion in rat pancreatic ducts
  12. Possibilities for clinical use of prostacyclin in vascular disease
  13. Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts
  14. Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto-Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis
  15. From taste to touch: sensory signaling in model organisms
  16. Expression and function of K v 7 channels in murine myometrium throughout oestrous cycle
  17. Regulation of voltage-gated sodium current by endogenous Src family kinases in cochlear spiral ganglion neurons in culture
  18. Tumor suppressor gene adenomatous polyposis coli downregulates intestinal transport
  19. Macrophages in vascular inflammation and atherosclerosis
  20. Sex differences in cardiac autonomic regulation and in repolarisation electrocardiography
  21. The effects of inhibiting myosin light chain kinase on contraction and calcium signalling in human and rat myometrium
  22. Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle
  23. Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle
  24. Endoplasmic reticulum–mitochondria coupling: local Ca 2+ signalling with functional consequences
  25. Intercellular and extracellular mechanotransduction in cardiac myocytes
  26. Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy
  27. P2X purinoceptors and sensory transmission
  28. Phenotype analysis of mice deficient in the peptide transporter PEPT2 in response to alterations in dietary protein intake
  29. Antagonism of stromal cell-derived factor-1α reduces infarct size and improves ventricular function after myocardial infarction
  30. Role of smooth muscle cell mineralocorticoid receptor in vascular tone
  31. Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
  32. P2X 3 receptor gating near normal body temperature
  33. Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
  34. Pathophysiology of HCN channels
  35. Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats
  36. Alterations in single muscle fiber calcium sensitivity with resistance training in older women
  37. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor
  38. Allosteric regulation of the P2X4 receptor channel pore dilation
  39. Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress
  40. Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse
  41. lnterleukin-6 (IL-6) and soluble receptors for interleukin-2 (slL-2R) in the diagnosis of early severe infection in the critically ill newborns
  42. Influence of neonatal sympathectomy on proximal renal resistance artery function in spontaneously hypertensive rats
  43. The effect of high-intensity exhaustive exercise studied in isolated mitochondria from human skeletal muscle
  44. Regulation of mineral metabolism by lithium
  45. Enhancement of the Shaker B Δ6–46 current by fatty acids depends on the activation of the lipoxygenase metabolic pathway
  46. Interactions of temperature and angiotensin II in paraventricular neurons of rats in vitro
  47. Contribution of calcium-conducting channels to the transport of zinc ions
  48. Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium
  49. A brief history of trp : commentary and personal perspective
  50. Glutamate receptors, neurotoxicity and neurodegeneration
  51. The I Cl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP 2
  52. Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K + channel by AFM recognition imaging
  53. Circadian variation in the effects of nitric oxide synthase inhibitors on body temperature, feeding and activity in rats
  54. Regulated acid–base transport in the collecting duct
  55. Piezo1-dependent regulation of urinary osmolarity
  56. AQP1 mediates water transport in the carotid body
  57. Closure of multiple types of K + channels is necessary to induce changes in renal vascular resistance in vivo in rats
  58. Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins
  59. Editorial
  60. Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype
  61. Insulin-independent glycogen supercompensation in isolated mouse skeletal muscle: role of phosphorylase inactivation
  62. Enhanced desensitization followed by unusual resensitization in GABA A receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice
  63. Sensitisation of TRPV4 by PAR 2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase
  64. Opioid receptor-mediated effects of interleukin-2 on the [Ca 2+ ] i transient and contraction in isolated ventricular myocytes of the rat
  65. cAMP- and cGMP-independent stretch-induced changes in the contraction of rat atrium
  66. Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells
  67. SGK1 activity in Na + absorbing airway epithelial cells monitored by assaying NDRG1-Thr 346/356/366 phosphorylation
  68. Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms
  69. An Editor’s farewell!
  70. Effects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1
  71. Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells
Search Result: