Authors: V A Kashkin P De Witte
Publish Date: 2003/12/22
Volume: 26, Issue: 2, Pages: 117-124
Abstract
Research has suggested that catalase plays a role in mediating ethanol’s psychopharmacological effects Catalase is an enzyme that oxidizes ethanol to acetaldehyde It has been reported that when catalase activity is reduced by 3amino124triazole AT rats reduce their intake and preference for ethanol The present study assessed the effects of AT on the brain amino acids levels following ethanol administration in Wistar rats The study consisted of three parts In the first part we found no effects of acute and chronic intraperitoneally administered acetaldehyde on amino acids dialysate levels in nucleus accumbens In the second part AT was administered five hours prior to ethanol or its vehicle Ethanol significantly affected the levels of taurine in rat pretreated with AT In the final part ethanol was administered following the pretreatment with AT but the dependent variable was the concentration of ethanol in the brain
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