Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Amino Acids

Search In Journal Title:

Abbravation: Amino Acids

Search In Journal Abbravation:

Publisher

Springer Vienna

Search In Publisher:

ISSN

1438-2199

Search In ISSN:
Search In Title Of Papers:

Safety of longterm dietary supplementation with

Authors: Ying Yang Zhenlong Wu Sichao Jia Sudath Dahanayaka Shuo Feng Cynthia J Meininger Catherine J McNeal Guoyao Wu
Publish Date: 2015/05/07
Volume: 47, Issue: 9, Pages: 1909-1920
PDF Link

Abstract

This study was conducted with rats to determine the safety of longterm dietary supplementation with larginine Beginning at 6 weeks of age male and female rats were fed a caseinbased semipurified diet containing 061  larginine and received drinking water containing larginineHCl 0 18 or 36 g larginine/kg bodyweight/day n = 10/group These supplemental doses of larginine were equivalent to 0 286 and 573 mg larginine/kg bodyweight/day respectively in humans After a 13week supplementation period blood samples were obtained from rats for biochemical analyses Supplementation with larginine increased plasma concentrations of arginine ornithine proline homoarginine urea and nitric oxide metabolites without affecting those for lysine histidine or methylarginines while reducing plasma concentrations of ammonia glutamine free fatty acids and triglycerides lArginine supplementation enhanced protein gain and reduced whitefat deposition in the body Based on general appearance feeding behavior and physiological parameters all animals showed good health during the entire experimental period Plasma concentrations of all measured hormones except leptin did not differ between control and argininesupplemented rats lArginine supplementation reduced plasma levels of leptin Additionally larginine supplementation increased larginineglycine amidinotransferase activity in kidneys but not in the liver or small intestine suggesting tissuespecific regulation of enzyme expression by larginine Collectively these results indicate that dietary supplementation with larginine eg 36 g/kg bodyweight/day is safe in rats for at least 91 days This dose is equivalent to 40 g larginine/kg bodyweight/day for a 70kg person Our findings help guide clinical studies to determine the safety of longterm oral administration of larginine to humans

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Structural protein reorganization and fold emergence investigated through amino acid sequence permutations
  2. Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study
  3. Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer
  4. A fluorescence anisotropy-based assay for determining the activity of tissue transglutaminase
  5. Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct
  6. Strategies for comprehensive analysis of amino acid biomarkers of oxidative stress
  7. Tissue-specific responses to loss of transglutaminase 2
  8. Regulation of intestinal protein metabolism by amino acids
  9. Free amino acid production during tomato fruit ripening: a focus on l -glutamate
  10. Bacterial signaling and adaptation
  11. Gas chromatographic determination and mechanism of formation of D-amino acids occurring in fermented and roasted cocoa beans, cocoa powder, chocolate and cocoa shell
  12. 2-(Phenylethyl)ammonium hydrogensquarate hemihydrate: crystal structure, solid-state IR-spectroscopic and theoretical characterization
  13. Direct one-step labeling of cysteine residues on peptides with [ 11 C]methyl triflate for the synthesis of PET radiopharmaceuticals
  14. Near infrared spectroscopy compared to liquid chromatography coupled to mass spectrometry and capillary electrophoresis as a detection tool for peptide reaction monitoring
  15. EPR spin-trapping of protein radicals to investigate biological oxidative mechanisms
  16. Kinetic study of racemization of aspartyl residues in synthetic elastin peptides
  17. Proteomics analysis of sensitive and tolerant barley genotypes under drought stress
  18. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression
  19. Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen–glucose deprivation-induced damage
  20. Cardiovascular actions of l -cysteine and l -cysteine sulfinic acid in the nucleus tractus solitarius of the rat
  21. Synthesis of 4-thia-[6- 13 C]lysine from [2- 13 C]glycine: access to site-directed isotopomers of 2-aminoethanol, 2-bromoethylamine and 4-thialysine
  22. The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects
  23. Selective regulation of polyamine metabolism with methylated polyamine analogues
  24. Circular dichroism and cross-linking studies of bacteriorhodopsin mutants
  25. LC/MS evaluation of metabolism and membrane transport of bombesin peptides
  26. Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): Overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5)
  27. Pitfalls in the synthesis of fluorescent methotrexate oligopeptide conjugates
  28. Regulation of apoptosis by protein S-nitrosylation
  29. Ethanol but not acetaldehyde induced changes in brain taurine: a microdialysis study
  30. Using the concept of Chou’s pseudo amino acid composition to predict protein subcellular localization: an approach by incorporating evolutionary information and von Neumann entropies
  31. WRF-TMH: predicting transmembrane helix by fusing composition index and physicochemical properties of amino acids
  32. Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni
  33. Acid-induced unfolding of didecameric keyhole limpet hemocyanin: detection and characterizations of decameric and tetrameric intermediate states
  34. Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans?
  35. Dual effect of chloramphenicol peptides on ribosome inhibition
  36. Synthesis of C5-tetrazole derivatives of 2-amino-adipic acid displaying NMDA glutamate receptor antagonism
  37. Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development
  38. Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscle
  39. Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development
  40. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway
  41. Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
  42. Nardilysin in human brain diseases: both friend and foe
  43. Natural structural diversity within a conserved cyclic peptide scaffold
  44. Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis
  45. Positioning of aminopeptidase inhibitors in next generation cancer therapy
  46. Optimal and effective oral dose of taurine to prolong exercise performance in rat
  47. S-adenosylmethionine and its products
  48. Influence of l β-, d α- and d β-Asp isomers of the Asp-76 residue on the properties of αA-crystallin 70–88 peptide
  49. Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells
  50. Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian d -aspartate oxidase
Search Result: