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Title of Journal: Amino Acids

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Abbravation: Amino Acids

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Springer Vienna

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DOI

10.1007/bf01660292

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ISSN

1438-2199

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Structural protein reorganization and fold emergen

Authors: Giovanni Minervini Alessandro Masiero Emilio Potenza Silvio C E Tosatto
Publish Date: 2014/10/21
Volume: 47, Issue: 1, Pages: 147-152
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Abstract

Correlation between random amino acid sequences and protein folds suggests that proteins autonomously evolved the most stable folds with stability and function evolving subsequently suggesting the existence of common protein ancestors from which all modern proteins evolved To test this hypothesis we shuffled the sequences of 10 natural proteins and obtained 40 different and apparently unrelated folds Our results suggest that shuffled sequences are sufficiently stable and may act as a basis to evolve functional proteins The common secondary structure of modern proteins is well represented by a small set of permuted sequences which also show the emergence of intrinsic disorder and aggregationprone stretches of the polypeptide chain

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